Osmosis Jones

August 10th, 2001


more trailers Osmosis Jones

Still of Bill Murray and Molly Shannon in Osmosis JonesOsmosis JonesOsmosis JonesOsmosis JonesOsmosis JonesOsmosis Jones

A policeman white blood cell, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

Release Year: 2001

Rating: 6.0/10 (14,050 voted)

Critic's Score: 57/100

Director: Bobby Farrelly

Stars: Laurence Fishburne, Chris Rock, David Hyde Pierce

Frank Detomello is a slovenly zookeeper, and simple father to the only young and bright girl named Shane, who catches a cold right after when he swallowed a germ-ridden egg! The inside of his body is known as the "City of Frank". An unlikely hero of a policeman white blood cell, by the name of Osmosis Jones works as a member of Immunity, for Frank's immune system, as a white blood cell. But with that germ-ridden egg comes a mortal danger: Osmosis discovers Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and plotting to ultimately overheat Frank's body, killing him from the inside out! Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death in 48 hours, breaking previous medical records! Meanwhile the pill that Frank took...

Chris Rock - Osmosis Jones(voice)
Laurence Fishburne - Thrax(voice)
David Hyde Pierce - Drix(voice)
Brandy Norwood - Leah(voice)
William Shatner - Mayor Phlegmming(voice)
Ron Howard - Tom Colonic(voice)
Kid Rock - Kidney Rock(voice)
Kenny Olson - Kidney Rock(voice)
Jason Krause - Kidney Rock(voice)
Joe C. - Kidney Rock(voice)
Stefanie Eulinberg - Kidney Rock(voice)
Jimmie Bones - Kidney Rock(voice)
Uncle Kracker - Kidney Rock(voice)
Jonathan Adams - Additional Character Voice(voice)
Carlos Alazraqui - Additional Character Voice(voice)

Taglines: Every Body Needs A Hero.


Official Website: Warner Bros. [United States] |

Release Date: 10 August 2001

Filming Locations: Plymouth, Massachusetts, USA

Box Office Details

Budget: $75,000,000(estimated)

Opening Weekend: $5,271,248 (USA) (12 August 2001) (2305 Screens)

Gross: $13,596,911 (USA) (7 October 2001)

Technical Specs


Did You Know?

In the bladder sequence, you can see one of the characters carrying Pikachu as a pet.

Errors made by characters (possibly deliberate errors by the filmmakers): On a diagram of Frank's body, the word collarbone is spelled as 'collerbone'.

[after Thrax escaped from Frank's memories]
Thrax: This guy sure was sick before I came here.

User Review

Very inventive!

Rating: 7/10

Okay, I think I've found the Sadly Underrated Movie of the Year.

I think that, between this and "the Iron Giant", Warner Brothers Animation has GOT to spring for a better promotion department. Really, all they'd have to say is something like: "We just let the creators of 'Something About Mary' and 'Dumb and Dumber' make their own cartoon. Brace yourselves."

All complaints aside, and none of them are really the movie's fault, this is one of the most inventive animated films I've seen in a very long time. The characters and backgrounds are allowed to look and move in ways that are downright refreshingly bizarre. The visuals are very imaginative. The humor, while funny, is still very much what you'd expect from a Farelly Brothers movie that takes place inside a very sick man, so I wouldn't recommend it to little kids or the weak of stomach. If you have a little future A+P major, however, this is going to blow their mind. Give it a look!